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BioXcell代理欣博盛生物:InVivoPlus anti-mouse PD-L1 (B7-H1)

更新時(shí)間:2023-05-18   點(diǎn)擊次數(shù):475次

BioXcell熱銷產(chǎn)品推薦--InVivoPlus anti-mouse PD-L1 (B7-H1)


產(chǎn)品描述:

BioXcell InVivoPlus anti-mouse PD-L1 10F.9G2單克隆抗體與小鼠PD-L1(也稱為B7-H1或CD274)反應(yīng)。PD-L1是屬于Ig超家族的B7家族的I型跨膜蛋白,分子量為40kDa。PD-L1在T淋巴細(xì)胞、B淋巴細(xì)胞、NK細(xì)胞、樹突狀細(xì)胞以及IFNγ刺激的單核細(xì)胞、上皮細(xì)胞和內(nèi)皮細(xì)胞上表達(dá)。PD-L1與CD4和CD8胸腺細(xì)胞以及活化的T和B淋巴細(xì)胞和骨髓細(xì)胞上的受體PD-1結(jié)合。PD-L1與PD-1的結(jié)合導(dǎo)致抑制TCR介導(dǎo)的T細(xì)胞增殖和細(xì)胞因子產(chǎn)生。PD-L1被認(rèn)為在腫瘤免疫逃逸中起著重要作用。誘導(dǎo)的PD-L1表達(dá)在許多腫瘤中很常見,并導(dǎo)致腫瘤細(xì)胞對(duì)CD8 T細(xì)胞介導(dǎo)的裂解的抗性增加。在黑色素瘤的小鼠模型中,可以通過用阻斷PD-L1和PD-1之間相互作用的抗體進(jìn)行治療,暫時(shí)抑制腫瘤生長。10F.9G2抗體已被證明可以阻斷PD-L1和PD-1之間以及PD-L1和B7-1之間的相互作用(CD80)。

BioXcell熱銷產(chǎn)品推薦--InVivoPlus anti-mouse PD-L1 (B7-H1) 

產(chǎn)品詳情:

產(chǎn)品名稱

InVivoPlus anti-mouse PD-L1 (B7-H1)

產(chǎn)品貨號(hào)

BP0101

產(chǎn)品規(guī)格

5/25/50/100mg

反應(yīng)種屬

Mouse

克隆號(hào)

10F.9G2

同種型

Rat IgG2b, κ

免疫原

Mouse CD274

實(shí)驗(yàn)應(yīng)用

in vivo PD-L1 blockade
Immunofluorescence
Immunohistochemistry (frozen)
Flow cytometry
Western blot

產(chǎn)品形式

PBS, pH 6.5,Contains no stabilizers or preservatives

純度

>95%, Determined by SDS-PAGE

聚合

<5%, Determined by SEC

無菌處理

0.2 µm filtration

純化方式

Protein G

RRID

AB_10949073

分子量

150 kDa

小鼠病原檢測(cè)

Ectromelia/Mousepox Virus: Negative

Hantavirus: Negative

K Virus: Negative

Lactate Dehydrogenase-Elevating Virus: Negative

Lymphocytic Choriomeningitis virus: Negative

Mouse Adenovirus: Negative

Mouse Cytomegalovirus: Negative

Mouse Hepatitis Virus: Negative

Mouse Minute Virus: Negative

Mouse Norovirus: Negative

Mouse Parvovirus: Negative

Mouse Rotavirus: Negative

Mycoplasma Pulmonis: Negative

Pneumonia Virus of Mice: Negative

Polyoma Virus: Negative

Reovirus Screen: Negative

Sendai Virus: Negative

Theiler’s Murine Encephalomyelitis: Negative

保存條件

抗體原液保存在4°C,不能冷凍保存。

推薦同型對(duì)照

InVivoPlus rat IgG2b isotype control, anti-keyhole limpet hemocyanin(貨號(hào)BP0090)

推薦抗體稀釋液

InVivoPure pH 6.5 Dilution Buffer(貨號(hào)IP0065)

 


為什么選擇InVivoPlus抗體?

InVivoPlus級(jí)別的產(chǎn)品內(nèi)毒素含量更低,經(jīng)過多種實(shí)驗(yàn)驗(yàn)證,更適合用于體內(nèi)實(shí)驗(yàn)研究

BioXcell熱銷產(chǎn)品推薦--InVivoPlus anti-mouse PD-L1 (B7-H1)


該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用,品質(zhì)有保證,以下是部分已發(fā)表的文獻(xiàn)引用:



應(yīng)用

文章

體內(nèi)PD-L1阻斷

(in vivo PD-L1 blockade)

1. Grasselly, C., et al. (2018). 'The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent' Front Immunol 9: 2100.

2. Stathopoulou, C., et al. (2018). 'PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells' Immunity 49(2): 247-263 e247.

3. Kim, J., et al. (2015). 'Memory programming in CD8(+) T-cell differentiation is intrinsic and is not determined by CD4 help' Nat Commun 6: 7994.

體內(nèi)PD-L1阻斷,流式細(xì)胞術(shù)

(in vivo PD-L1 blockade, Flow Cytometry)

1. Aloulou, M., et al. (2016). 'Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells' Nat Commun 7: 10579.

2. Ngiow, S. F., et al. (2015). 'A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1' Cancer Res 75(18): 3800-3811.

3. Rutigliano, J. A., et al. (2014). 'Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8+ T cells' J Virol 88(3): 1636-1651.

體內(nèi)PD-L1阻斷,免疫熒光

(in vivo PD-L1 blockade, Immunofluorescence)

1.Willimsky, G., et al. (2013). 'Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance' J Clin Invest 123(3): 1032-1043.

免疫組織化學(xué)(冷凍切片),免疫熒光

(Immunohistochemistry (frozen), Immunofluorescence)

1.Riella, L. V., et al. (2011). 'Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts' Am J Transplant 11(4): 832-840.



 

BioXcell熱銷產(chǎn)品推薦--InVivoPlus anti-mouse PD-L1 (B7-H1) 

更多產(chǎn)品詳情請(qǐng)聯(lián)系 BioXcell 中國授權(quán)代理——欣博盛生物


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