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InVivoSIM anti-human amyloid beta (Donanemab Biosimilar) clone: Donanemab (Catalog #SIM0048)
InVivoSIM 抗人類淀粉樣 β (Donanemab 生物仿制藥)抗 體,克?。篋onanemab(目錄號(hào) #SIM0048)
Key features(主要特點(diǎn)):
1. Donanemab biosimilar is a humanized IgG1κ antibody against human amyloid-β protein precursor (APP).
2. Specifically reacts with abeta 42 (Aβ42) that drives the pathogenesis of Alzheimer’s disease (AD).
3. Donanemab biosimilars impede the progression of AD by clearing plaques through microglialmediated phagocytosis in mice without causing microhemorrhages.
4. Studies involving Alzheimer's disease and Down syndrome experimental models use the donanemab biosimilar
1. Donanemab 生物仿制藥是一種針 對(duì)人類淀粉樣 β 蛋白前體(APP) 的重組人源化 IgG1κ 抗體。
2. 特異性識(shí)別 Aβ42,Aβ42 驅(qū)動(dòng)阿爾 茨海默癥(AD)的發(fā)病機(jī)制。
3. Donanemab 生物仿制藥通過小膠 質(zhì)細(xì)胞介導(dǎo)的吞噬作用清除斑塊, 從而阻止 AD 的進(jìn)展,同時(shí)不會(huì)引 起微出血。
4. Donanemab 生物仿制藥被用于阿 爾茨海默癥和唐氏綜合征實(shí)驗(yàn)?zāi)P?的研究。
Application(應(yīng)用): in vivo functional assays, in vitro functional assays, ELISA, Western blot
體內(nèi)功能實(shí)驗(yàn)、體外功能實(shí)驗(yàn)、ELISA、 Western Blot
Research Area(研究領(lǐng)域): Neuroscience/神經(jīng)科學(xué)
Related targets(相關(guān)靶點(diǎn)): Amyloid-beta, CD11b, TNF-α, IL-6, IL-3, VEGFR-2
淀粉樣 β、CD11b、TNF-α、IL-6、IL-3、 VEGFR-2
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