Aconitine

更新時(shí)間：2022-01-28

簡要描述：

A lipid-soluble neurotoxin that acts as a sodium channel modulator. Binds with high affinity to the open state of the voltage-sensitive sodium channels at site 2, thereby causing a persistent ……

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A lipid-soluble neurotoxin that acts as a sodium channel modulator. Binds with high affinity to the open state of the voltage-sensitive sodium channels at site 2, thereby causing a persistent activation of the sodium channels, which become refractory to excitation.

Product Details

Alternative Name:	(1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate

Formula:	C34H47NO11

MW:	645.7

Source:	Isolated from Aconitum karacolium.

CAS:	302-27-2

MI:	14: 118

RTECS:	AR5960000

Purity:	≥98% (HPLC)

Appearance:	White to off-white powder.

Solubility:	Soluble in 100% ethanol (35mg/ml); almost insoluble in water (0.3mg/ml).

Shipping:	Ambient

Long Term Storage:	+4°C

Handling:	Protect from light.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Non-quantal acetylcholine release at mouse neuromuscular junction: effects of elevated quantal release and aconitine: S.P. Yu & W. Van der Kloot; Neurosci. Lett. 117, 111 (1990), Abstract;

Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids: M. Muroi, et al.; Neuropharmacology 29, 567 (1990), Abstract;

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Aconitine

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