蜜臀av性久久久久蜜臀av_久久精品国产亚洲av超碰_国产精品福利小视频_午夜少妇

產(chǎn)品中心您現(xiàn)在的位置:首頁 > 產(chǎn)品展示 > > 免疫佐劑 > MPLAs Vaccigrade™

MPLAs Vaccigrade™

更新時(shí)間:2022-01-29

簡(jiǎn)要描述:

Synthetic lipid A
Synthetic lipid A from E. coli, serotype R515 (MPLAs) is a pure monophosphoryl lipid A compound produced by chemical synthesis.
MPLAs activates TLR4 but does not activate TLR2 refle…

型號(hào):廠商性質(zhì):代理商瀏覽量:872

Synthetic lipid A

Synthetic lipid A from E. coli, serotype R515 (MPLAs) is a pure monophosphoryl lipid A compound produced by chemical synthesis.
MPLAs activates TLR4 but does not activate TLR2 reflecting its high purity. MPLAs contains 6 fatty acyl groups, while MPLA purified from bacteria contains a mixture of 5, 6, and 7 acyl lipid A.

MPLA has been tested as an adjuvant in mice and reported to induce a strong Th1 response.

MPLAs VacciGrade™ is suitable for preclinical studies. It is prepared under strict aseptic conditions. It is guaranteed sterile.

MPLAs VacciGrade™ is for research use only, not for use in humans.


Specifications

Specificity: TLR4 agonist - Th1 response

Working concentration: 2- 20 μg/mouse

Quality: Sterile

Molecular weight: 1763.47

CAS Number: 1246298-63-4

Solubility: 1 mg/ml in DMSO

Quality control:

  • MPLAs VacciGrade™ is a preclinical grade.

  • It is prepared under strict aseptic conditions.

  • MPLAs VacciGrade™ is guaranteed sterile.


Contents

MPLAs VacciGrade™ is provided as a clear, lipidic film.

  • 1 mg MPLAs VacciGrade™

  • 10 ml sterile endotoxin-free physiological water (NaCl 0.9%)

room temperature MPLAs VacciGrade™ is shipped at room temperature.

store Store at -20?C.

stable Product is stable 1 year when properly stored.

Upon resuspension, prepare aliquots of MPLAs VacciGrade™ and store at -20?C.

Resuspended product is stable 6 months when properly stored.

Avoid repeated freeze-thaw cycles.


Details

MPLA is a low-toxicity derivative of lipopolysaccharide (LPS), that retains the immunologically active lipid A portion of the parent molecule [1]. While the toxicity associated with LPS prohibits its potential clinical use, MPLA is being developed as a vaccine adjuvant [2]. Both LPS and MPLA are TLR4 agonists, but they signal through different adaptors, MyD88 and TRIF, respectively. The reduced toxicity of MPLA is attributed to the preferential recruitment of TRIF upon TLR4 activation, resulting in decreased induction of inflammatory cytokines [3].

MPLA has been tested as an adjuvant in mice and reported to induce a strong Th1 response [4-5]. Although the mechanism of action of MPLA has not been fully eludicated, it has been suggested that MPLA improves vaccine immunogenicity by enhancing antigen presenting cell maturation [6].

 

1. Okemoto K. et al., 2006. A potent adjuvant monophosphoryl lipid A triggers various immune responses, but not secretion of IL-1beta or activation of caspase-1. J Immunol. 176(2):1203-8.
2. Casella CR. et al., 2008. Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant. Cell Mol Life Sci. 65(20):3231-40.
3. Mata-Haro V. et al., 2007. The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science. 316(5831):1628-32.
4. Fransen F. et al., 2007. Agonists of Toll-like receptors 3, 4, 7, and 9 are candidates for use as adjuvants in an outer membrane vaccine against Neisseria meningitidis serogroup. Infect Immun. 75(12) :5939-46.
5. Rhee EG. et al., 2010. TLR4 Ligands Augment Antigen-Specific CD8+ T Lymphocyte Responses Elicited by a Viral Vaccine Vector. J. Virol. 84: 10413 - 10419.
6. Didierlaurent A. et al., 2009. AS04, an aluminum salt- and TLR4 agonistbased adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity. J Immunol 183(10): 6186-97.


如需購買或咨詢?cè)摦a(chǎn)品技術(shù)問題,請(qǐng)聯(lián)系Invivogen一級(jí)代理商--欣博盛生物

留言框

  • 產(chǎn)品:

  • 您的單位:

  • 您的姓名:

  • 聯(lián)系電話:

  • 常用郵箱:

  • 省份:

  • 詳細(xì)地址:

  • 補(bǔ)充說明:

  • 驗(yàn)證碼:

    請(qǐng)輸入計(jì)算結(jié)果(填寫阿拉伯?dāng)?shù)字),如:三加四=7
1000部丰满熟女视频| 亚洲精品一区二区三区三| 伦理精品一区二区三精品| 激情 小说 亚洲 图片 伦| 国产毛片一区二区三区| 亚洲视频在线观看| 欧美成人午夜精品久久久| 中文字幕人妻在线中文乱码| x88av蜜桃臀一区二区| 午夜精品久久久久久99热小说| 高清毛片aaaaaaaaa郊外| 亚洲码欧美码一区二区三区| 1024人妻一区二区三区| 中文字幕精品人妻| 尤物视频在线免费观看| 成人无码一区二区三区| 亚洲精品乱码久久久久久蜜桃91| 性少妇freesexvideos高清bbw| 99热精品在线观看| 68日本xxxxxxxxx59免费的 | 亚洲国产av一区| 91亚洲国产成人精品一区二三| 久久精品亚洲一区| 日韩精品一区二区三区视频| 国产精品国产自产拍高清av| 亚洲av在线观看| 成人精品免费在线观看| 国产精品久久久久久av福利软件| 99久久精品久久久久久ai换脸| 国产精品久久久久久久久久影院| 永久免费看黄网站| 少妇免费直播| 精品国产乱码久久久久久蜜臀| 亚洲国产av一区| 和尚吮她的花蒂和奶水视频网址 | 欧美老熟妇乱大交xxxxx| 两性免费视频| 国产精品三级久久久久三级| 国产乱码精品一区二区| 蜜臀久久精品久久久更新时间| 日韩高清毛片|